Ever since Adobe published InDesign in 2002, the competition between these two main design programs has been a main discussion of journalists and graphic designers. Our art director personally prefers InDesign over Quark Xpress.
“InDesign is part of a creative suite that is totally combatible with itself. Quark can’t do that. InDesign also has so many more effects you can put on objects, text, or photos,” Emily Leithauser, Exodus art director, said. “InDesign doesn’t limit my creativity.”
Read below for information on both programs and check out some websites that explain the competitive edge InDesign seems to have over Quark.
InDesign CS4
“Adobe InDesign is a desktop publishing (DTP) software application produced by Adobe Systems which can be used to create anything from posters, flyers, and brochures to full magazines or books.” (wikipedia)

Quark Xpress
“QuarkXPress (“Quark”) is a computer application for creating and editing complex page layouts in a WYSIWYG environment. It runs on Mac OS X and Windows. It was first released by Quark, Inc. in 1987 and is still owned and published by them.” (wikipedia)
Websites to visit:
“Adobe InDesign vs. Quark Xpress”
Or buy InDesign!
Which program do you prefer?
I vote InDesign. It flexes with Photoshop and it has a few nice tools that Quark doesn’t offer. Quark, meanwhile, has felt stagnant for some time.
Quark used to be the one and only, unfortunately for them Adobe used the mass market they had in the graphics field along with competitive pricing to beat Quark hands down. So being an Adobe user and price playing an important part I have to also vote InDesign, shame for the little guy.